The second season begins eight hours after the escape, focusing mainly on the man escaping from the prison. Prisoners separate, flee and hide throughout the country, while the authorities are following closely behind, chase them for different purposes. Brad Bellick - the warden of the jail was sacked and joined the hunt for colossal bonuses. Some of those who escaped uniting to find a big buck was hidden by another prisoner.

• Prison Break
• Paul Scheuring
• Dominic Purcell
• Wentworth Miller
• Amaury Nolasco